EXPLORE THE MAGIC OF MINOR CANNABINOIDS
THE ENTOURAGE EFFECT
As cannabis gains greater legal acceptance, more data on its use will become available which both could and should be used to shed light on the effects of cannabinoids. A popular theme in this area is the idea of a polypharmacy, or “entourage effect”, the whole of cannabis being greater than the sum of its parts. The effect is assumed to arise from cannabinoids’ interactions with and alongside one another – as well as with other, non-cannabinoid, compounds – which may enhance any given effect. While there is merit to this view, some are sceptical, particularly in the context of generating the evidence required to support a potential therapy. In contrast to the development of a typical pharmaceutical, where a promising compound found in a laboratory progresses through increasing layers of scrutiny, generating an ever-stronger evidence base for a particular mechanism of action, the promise of cannabis is reversed, arising through its long, popular, and successful use as a compound with several active components (and potential mechanisms of action) all present at once. While much has been uncovered about the parts that make up cannabis, many questions remain about the effects and actions of minor cannabinoids. Understanding any one of these is best achieved within the context of other similar cannabinoids, looking at potential shared mechanisms as well as the nature of the evidence and the evolution of the field as a whole to see which suite you the best. All in all, minor cannabinoids possess immense promise as a means to leverage the medicinal value of cannabis by better targeting specific conditions and personal preferences. Try for yourself , and experience the magic of minor cannabinoids.
DELTA 8 THC
What is Delta 8 THC? Delta-8-tetrahydrocannabinol (delta-8-THC, Δ8-THC) is a psychoactive cannabinoid found in the Cannabis plant. It is an isomer of delta-9-tetrahydrocannabinol (delta-9-THC, Δ9-THC), the compound commonly known as THC. ∆8-THC has antiemetic, anxiolytic, orexigenic, analgesic, and neuroprotective properties. ∆8-THC is slightly less potent than Δ9-THC (being about ≈50-66% as potent in-vivo according to most scientific studies on the topic), although its psychological and physiological effects remain qualitatively similar. This essentially means that it will still medicate similarly to ∆9-THC, although to a lesser degree per milligram of material consumed. Delta 8 THC was made legal by H.R. 2: The Agricultural Improvement Act of 2018, commonly referred to as the 2018 Farm Bill. It was specifically made legal when hemp allowed for all derivatives, isomers, and cannabinoids of hemp that were not Delta 9 THC. Up to that point, D8 THC had been illegal and was specifically named in the Controlled Substances Act. However, in addition to making all hemp cannabinoids, isomers, and derivatives legal, H.R. 2 specifically includes text to remove all confusion between laws by amending the Controlled Substances Act to exclude Delta 8 THC from hemp. Delta 8 THC is federally legal and legal in most states, but it is not legal in all states.
What is CBN? Cannabinol, or CBN, is a mildly psychoactive component found in cannabis which, like strongly psychoactive THC, is derived from tetrahydrocannabinolic acid (THC-A). CBN is created when THC-A oxidizes. CBN can be used effectively as a sleep aid or sedative. This cannabinoid has also been shown to help regulate the immune system and works to relieve the pain and inflammation caused by several conditions, including arthritis and Crohn’s disease. Studies show that it can be used to reduce the intraocular eye pressure caused by glaucoma. CBN acts as an anticonvulsant, so it is also beneficial to patients suffering from seizure disorders including epilepsy.
What is CBC? Cannabichromene, or CBC, is a powerful, non-psychoactive cannabinoid, meaning it will not cause a patient to feel “high.” CBC, like THC and CBD, has been shown to encourage the human brain to grow by increasing the viability of developing brain cells in a process known as neurogenesis. CBC plays a significant role in the anti-cancer and anti-tumor capabilities of cannabis. CBC battles inflammation by activating the CB2 receptor. However, because it does not activate CB1, the healing potential of CBC could be enhanced when combined with cannabinoids that do, such as THC.
What is CBG? Cannabigerol, or CBG, is a non-psychoactive cannabinoid typically most abundant in low-THC and high-CBD cannabis strains, including hemp. Like THC, CBG reacts with the cannabinoid receptors in the brain. CBG, however, acts as a buffer to the psychoactivity of THC by working to alleviate the paranoia sometimes caused by higher levels of THC. CBG works to fight inflammation, pain, nausea and works to slow the proliferation of cancer cells. Research has shown it also significantly reduces intraocular eye pressure caused by glaucoma. Strains high in CBG will be beneficial treating conditions such as inflammatory bowel disease, Crohn’s disease, and cancer. It’s often referred to as the mother of all cannabinoids. This is because other cannabinoids are derived from cannabigerolic acid (CBGA), an acidic form of CBG. Other more common cannabinoids obtained from cannabis plants include cannabidiol (CBD) and tetrahydrocannabinol (THC). CBG is found in smaller quantities than other cannabinoids in cannabis plants. In most strains of the plant, only 1% of CBG can be found compared to 20 to 25% of CBD or 25 to 30% of THC.1 This makes consumer products derived from the cannabinoid rare and often expensive. However, CBG is growing in popularity as a result of the host of potential benefits the cannabinoid has to offer. CBG works by binding to both receptors where it’s thought to strengthen the function of anandamide, a neurotransmitter that plays a role in enhancing pleasure and motivation, regulating appetite and sleep, and alleviating pain.
Cannabidiol, or CBD, is the non-psychoactive cannabinoid famed for significantly reducing symptoms in patients suffering from seizure and spasm disorders such as epilepsy and multiple sclerosis. CBD is the cannabinoid most often recommended for children, elderly and other patients who must remain clear-headed in their activities because it is non-psychoactive, meaning it will not produce euphoria or the feeling of being “high.” CBD reacts with cannabinoid receptors throughout the human body and works to relieve inflammation and pain while producing a calming effect in patients.